In vivo antiplasmodial activity of an aqueous extract of leafy stems of Ipomoea pes-caprea (L.) R.Br. in Swiss mice infected with Plasmodium berghei

نویسندگان

چکیده

The study aimed to evaluate the in vivo antiplasmodial activity of an aqueous extract aerial parts Ipomoea pes-caprea mice infected with Plasmodium berghei. Extracts were obtained from decoction dried leafy stem plant. extracts used for evaluation which was done according two methods: Rane test curative effect while Peters suppressive effect. Four concentrations (25, 50, 100 and 200 mg/kg) administered orally during tests. results showed a dose-dependent decrease parasitaemia. dose mg/kg bwt inhibited parasitaemia percentage suppression equal 50.89% without resulting significant body weight loss animals (p?0.05), but showing survival rate identical that chloroquine. This I. has properties at against P. It would be good candidate tested human parasite, is, falciparum, development other antimalarial drugs. Key words: Antiplasmodial activity, pes-caprea,

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ژورنال

عنوان ژورنال: African Journal of Pharmacy and Pharmacology

سال: 2022

ISSN: ['1996-0816']

DOI: https://doi.org/10.5897/ajpp2022.5297